Oprah Winfrey points to the crowd during a taping celebrating the 24th season of the Oprah Winfrey Show in Chicago, in this September 8, 2009 file photo. Winfrey will end her TV chat show at the end of its 25th season in September 2011, her production company Harpo Inc said on November 19, 2009.

Oprah Winfrey points to the crowd during a taping celebrating the 24th season of the Oprah Winfrey Show in Chicago, in this September 8, 2009 file photo. Winfrey will end her TV chat show at the end of its 25th season in September 2011, her production company Harpo Inc said on November 19, 2009.

"I love this show. This show has been my life. And I love it enough to know when it is time to say good-bye," said Winfrey, holding back tears.

"Twenty-five years feels right in my bones and it feels right in my spirit. It is the perfect number, the exact right time," Winfrey said at the end of her hour-long show broadcast live from the city.

Speculation has been rife that she is bringing the curtains down on 'The Oprah Winfrey Show' because she is preparing to launch her cable network - OWN -The Oprah Winfrey Network in association with Discovery Communications.

However, Winfrey sought to put to rest the conjecture saying, "Over the next couple of days, you may hear a lot of speculation in the press about why I am making this decision now...and that will mostly be conjecture.